Amantadine was the first antiviral used to suppress influenza virus, and it was approved as a prophylactic drug by the United States in 1966 for Asian influenza. In 1976, it was confirmed as a therapeutic drug on the basis of preventive drugs. The efficacy and safety of the drug for adult patients have been widely recognized. However, the treatment dose is very close to the dose of side effects, and it is difficult to determine the dose and administration plan for the elderly and those with chronic cardiopulmonary disease or kidney disease, so it has not been widely used in clinical practice. Amantadine has been used as a treatment for Parkinson's disease in Japan until 1998, when it was approved for the treatment of influenza A infectious diseases.
White to cream powder
1. Antiviral drugs are also anti-seismic and paralytic drugs.
2. It is used for the synthesis of amantadine derivatives, amantadine salt, etc.
3. It is used in the synthesis of adamantane derivatives such as amantadine salt, etc. and the structural unit of l-piperidine amide catalyst, which can be used in the enantioselective Strecker reaction of phosphonimide.
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